Cryptochrome 2 variants, chronicity, and seasonality of mood disorders

MOOD DISORDERS AND MEDICAL ILLNESS Mood Disorders and Allostatic Load

The brain controls both the physiologic and the behavioral coping responses to daily events as well as major stressors, and the nervous system is itself a target of the mediators of those responses through circulating hormones. The amygdala and hippocampus interpret what is stressful and regulate appropriate responses. The amygdala becomes hyperactive in posttraumatic stress disorder (PTSD) and...

Seasonality in vestibular disorders.

Our objective in this study was to evaluate a causal relationship between vestibular pathological findings and climatic variations during the year (summer, autumn, winter, and spring). The study was conducted in a Brazilian clinic located in a tropical climate and having well-defined warm and cold weather. For this retrospective study, our outpatients were the subjects, and the diagnosis was ma...

Seasonality in affective disorders.

Humans retain neurobiological responses to circadian day-night cycles and seasonal changes in daylength in spite of a life-style usually independent of dawn-dusk signals. Seasonality has been documented in many functions, from mood to hormones to gene expression. Research on seasonal affective disorder initiated the first use of timed bright light as therapy, a treatment since extended to non-s...

Associations of Suicide Seasonality with Rural- Urban Residence and Mental Disorders in Ilam, Iran

Chronobiology and mood disorders

The clinical observations of diurnal variation of mood and early morning awakening in depression have been incorporated into established diagnostic systems, as has the seasonal modifier defining winter depression (seasonal affective disorder, SAD). Many circadian rhythms measured in depressive patients are abnormal: earlier in timing, diminished in amplitude, or of greater variability. Whether ...